IDRA-21 is an ampakine drug with anti-amnesic effects. (+)-IDRA-21 is the enantiomer that is biologically active.
In animal models, IDRA-21 improves learning and memory. It’s potency in reversing scopolamine or alprazolam-induced cognitive deficits is 10-30x that of aniracetam. Protracted effects up to 48 hours are observed after a single dose.
Like other ampakines, IDRA-21 mechanism converges on enhancement of long-term potentiation (LTP).
The potency of benzothiadiazide derivatives is as follows: CX-546 > IDRA-21 > CX-516.